Single-cell metabolic profiling reveals subgroups of primary human hepatocytes with heterogeneous responses to drug challenge

Abstract Background Xenobiotics are primarily metabolized by hepatocytes in the liver, and primary human hepatocytes are the gold standard model for the assessment of drug efficacy, safety, and toxicity in the early phases of drug development. Recent advances in single-cell genomics demonstrate live...

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Bibliographic Details
Main Authors: Eva Sanchez-Quant, Maria Lucia Richter, Maria Colomé-Tatché, Celia Pilar Martinez-Jimenez
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Genome Biology
Subjects:
Online Access:https://doi.org/10.1186/s13059-023-03075-9