Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection.

Antithetic effect of interferon-α on cell-free and cell-to-cell HIV-1 infection.

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In HIV-1-infected individuals, transmitted/founder (TF) virus contributes to establish new infection and expands during the acute phase of infection, while chronic control (CC) virus emerges during the chronic phase of infection. TF viruses are more resistant to interferon-alpha (IFN-α)-mediated ant...

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Bibliographic Details
Main Authors: Ryuichi Kumata, Shoya Iwanami, Katrina B Mar, Yusuke Kakizoe, Naoko Misawa, Shinji Nakaoka, Yoshio Koyanagi, Alan S Perelson, John W Schoggins, Shingo Iwami, Kei Sato
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2022-04-01
Series:PLoS Computational Biology
Online Access:https://doi.org/10.1371/journal.pcbi.1010053

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https://doi.org/10.1371/journal.pcbi.1010053

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