Development and characterization of a non-human primate model of disseminated synucleinopathy

Development and characterization of a non-human primate model of disseminated synucleinopathy

IntroductionThe presence of a widespread cortical synucleinopathy is the main neuropathological hallmark underlying clinical entities such as Parkinson’s disease with dementia (PDD) and dementia with Lewy bodies (DLB). There currently is a pressing need for the development of non-human primate (NHPs...

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Bibliographic Details
Main Authors: Alberto J. Rico, Almudena Corcho, Julia Chocarro, Goiaz Ariznabarreta, Elvira Roda, Adriana Honrubia, Patricia Arnaiz, José L. Lanciego
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-03-01
Series:Frontiers in Neuroanatomy
Subjects:
alpha-synuclein
Lewy body dementia
adeno-associated viral vectors
gene therapy
non-human primates
Parkinson’s disease
Online Access:https://www.frontiersin.org/articles/10.3389/fnana.2024.1355940/full

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https://www.frontiersin.org/articles/10.3389/fnana.2024.1355940/full

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