The role of MORC3 in silencing transposable elements in mouse embryonic stem cells

The role of MORC3 in silencing transposable elements in mouse embryonic stem cells

Abstract Background Microrchidia proteins (MORCs) are involved in epigenetic gene silencing in a variety of eukaryotic organisms. Deletion of MORCs result in several developmental abnormalities and their dysregulation has been implicated in developmental disease and multiple cancers. Specifically, m...

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Bibliographic Details
Main Authors: Varsha P. Desai, Jihed Chouaref, Haoyu Wu, William A. Pastor, Ryan L. Kan, Harald M. Oey, Zheng Li, Jamie Ho, Kelly K. D. Vonk, David San Leon Granado, Michael A. Christopher, Amander T. Clark, Steven E. Jacobsen, Lucia Daxinger
Format: Article
Language:English
Published: BMC 2021-10-01
Series:Epigenetics & Chromatin
Subjects:
MORC3
Endogenous retroviruses
MommeD screen
Chromatin regulators
IAPs
Online Access:https://doi.org/10.1186/s13072-021-00420-9

Internet

https://doi.org/10.1186/s13072-021-00420-9

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