Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms

Genome-wide polygenic risk score for major osteoporotic fractures in postmenopausal women using associated single nucleotide polymorphisms

Abstract Background Osteoporosis is highly polygenic and heritable, with heritability ranging from 50 to 80%; most inherited susceptibility is associated with the cumulative effect of many common genetic variants. However, existing genetic risk scores (GRS) only provide a few percent predictive powe...

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Bibliographic Details
Main Authors: Qing Wu, Jongyun Jung
Format: Article
Language:English
Published: BMC 2023-02-01
Series:Journal of Translational Medicine
Subjects:
GPS
GRS
GWAS
Fracture
Osteoporosis
Bone density
Online Access:https://doi.org/10.1186/s12967-023-03974-2

Internet

https://doi.org/10.1186/s12967-023-03974-2

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