Increased number of T cells and exacerbated inflammatory pathophysiology in a human IgG4 knock-in MRL/lpr mouse model.

Immunoglobulin (Ig) G4 is an IgG subclass that can exhibit inhibitory functions under certain conditions because of its capacity to carry out Fab-arm exchange, inability to form immune complexes, and lack of antibody-dependent and complement-dependent cytotoxicity. Although several diseases have bee...

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Bibliographic Details
Main Authors: Yoshie Gon, Tsugumitsu Kandou, Tatsuaki Tsuruyama, Takeshi Iwasaki, Koji Kitagori, Kosaku Murakami, Ran Nakashima, Shuji Akizuki, Akio Morinobu, Masaki Hikida, Tsuneyo Mimori, Hajime Yoshifuji
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2023-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0279389