A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence

A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence

Many strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.

Bibliographic Details
Main Authors: Sethu C. Nair, Ruixue Xu, Sittiporn Pattaradilokrat, Jian Wu, Yanwei Qi, Martine Zilversmit, Sundar Ganesan, Vijayaraj Nagarajan, Richard T. Eastman, Marlene S. Orandle, John C. Tan, Timothy G. Myers, Shengfa Liu, Carole A. Long, Jian Li, Xin-zhuan Su
Format: Article
Language:English
Published: Nature Portfolio 2017-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00267-3

Internet

https://doi.org/10.1038/s41467-017-00267-3

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