A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence
Many strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.
| Main Authors: | , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2017-08-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-017-00267-3 |
| _version_ | 1818995134118756352 |
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| author | Sethu C. Nair Ruixue Xu Sittiporn Pattaradilokrat Jian Wu Yanwei Qi Martine Zilversmit Sundar Ganesan Vijayaraj Nagarajan Richard T. Eastman Marlene S. Orandle John C. Tan Timothy G. Myers Shengfa Liu Carole A. Long Jian Li Xin-zhuan Su |
| author_facet | Sethu C. Nair Ruixue Xu Sittiporn Pattaradilokrat Jian Wu Yanwei Qi Martine Zilversmit Sundar Ganesan Vijayaraj Nagarajan Richard T. Eastman Marlene S. Orandle John C. Tan Timothy G. Myers Shengfa Liu Carole A. Long Jian Li Xin-zhuan Su |
| author_sort | Sethu C. Nair |
| collection | DOAJ |
| description | Many strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance. |
| first_indexed | 2024-12-20T21:09:01Z |
| format | Article |
| id | doaj.art-6aa7760b2b7b4b8286e3d15932c22045 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-20T21:09:01Z |
| publishDate | 2017-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6aa7760b2b7b4b8286e3d15932c220452022-12-21T19:26:33ZengNature PortfolioNature Communications2041-17232017-08-018111410.1038/s41467-017-00267-3A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulenceSethu C. Nair0Ruixue Xu1Sittiporn Pattaradilokrat2Jian Wu3Yanwei Qi4Martine Zilversmit5Sundar Ganesan6Vijayaraj Nagarajan7Richard T. Eastman8Marlene S. Orandle9John C. Tan10Timothy G. Myers11Shengfa Liu12Carole A. Long13Jian Li14Xin-zhuan Su15Malaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of HealthState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen UniversityMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of HealthMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of HealthMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of HealthMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of HealthBiological Imaging Section, Research Technology Branch, National Institute of Allergy and Infectious Disease, National Institutes of HealthBioinformatics and Computational Biosciences Branch, Office of Cyber Infrastructure and Computational Biology, National Institute of Allergy and Infectious Disease, National Institutes of HealthMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of HealthComparative Medicine Branch, National Institute of Allergy and Infectious Diseases, National Institutes of HealthThe Eck Institute of Global Health, Department of Biological Sciences, University of Notre DameGenomic Technologies Section, Research Technologies Branch, National Institute of Allergy and Infectious Disease, National Institutes of HealthState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen UniversityMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of HealthState Key Laboratory of Cellular Stress Biology, Innovation Center for Cell Signaling Network, School of Life Sciences, Xiamen UniversityMalaria Functional Genomics Section, Laboratory of Malaria and Vector Research, National Institute of Allergy and Infectious Disease, National Institutes of HealthMany strains of Plasmodium differ in virulence, but factors that control these distinctions are not known. Here the authors comparatively map virulence loci using the offspring from a P. yoelii YM and N67 genetic cross, and identify a putative HECT E3 ubiquitin ligase that may explain the variance.https://doi.org/10.1038/s41467-017-00267-3 |
| spellingShingle | Sethu C. Nair Ruixue Xu Sittiporn Pattaradilokrat Jian Wu Yanwei Qi Martine Zilversmit Sundar Ganesan Vijayaraj Nagarajan Richard T. Eastman Marlene S. Orandle John C. Tan Timothy G. Myers Shengfa Liu Carole A. Long Jian Li Xin-zhuan Su A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence Nature Communications |
| title | A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence |
| title_full | A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence |
| title_fullStr | A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence |
| title_full_unstemmed | A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence |
| title_short | A Plasmodium yoelii HECT-like E3 ubiquitin ligase regulates parasite growth and virulence |
| title_sort | plasmodium yoelii hect like e3 ubiquitin ligase regulates parasite growth and virulence |
| url | https://doi.org/10.1038/s41467-017-00267-3 |
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