Irinotecan Activates p53 With Its Active Metabolite, Resulting in Human Hepatocellular Carcinoma Apoptosis

Irinotecan Activates p53 With Its Active Metabolite, Resulting in Human Hepatocellular Carcinoma Apoptosis

The topoisomerase I inhibitor irinotecan is widely used in anticancer therapy, although the detailed mechanism is still unclear. We investigated the apoptotic mechanisms of irinotecan in human hepatocellular carcinoma (HCC) cell lines (Huh7). SN-38 caused a significant decrease in cell proliferation...

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Bibliographic Details
Main Authors: Yuko Takeba, Toshio Kumai, Naoki Matsumoto, Sachiko Nakaya, Yoshimitsu Tsuzuki, Yohei Yanagida, Shinichi Kobayashi
Format: Article
Language:English
Published: Elsevier 2007-01-01
Series:Journal of Pharmacological Sciences
Online Access:http://www.sciencedirect.com/science/article/pii/S1347861319342483

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http://www.sciencedirect.com/science/article/pii/S1347861319342483

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