A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway

A network pharmacology- and transcriptomics-based investigation reveals an inhibitory role of β-sitosterol in glioma via the EGFR/MAPK signaling pathway

Glioma is characterized by rapid cell proliferation, aggressive invasion, altered apoptosis and a poor prognosis. β-Sitosterol, a kind of phytosterol, has been shown to possess anticancer activities. Our current study aims to investigate the effects of β-sitosterol on gliomas and reveal the underlyi...

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Bibliographic Details
Main Authors: Xie Yufang, Chen Zhijian, Li Shuang, Yan Meijuan, He Wenjun, Li Li, Si Junqiang, Wang Yan, Li Xinzhi, Ma Ketao
Format: Article
Language:English
Published: China Science Publishing & Media Ltd. 2023-12-01
Series:Acta Biochimica et Biophysica Sinica
Subjects:
β-sitosterol
glioma
proliferation
G2/M phase arrest
apoptosis
EGFR/MAPK signaling pathway
Online Access:https://www.sciengine.com/doi/10.3724/abbs.2023251

Internet

https://www.sciengine.com/doi/10.3724/abbs.2023251

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