Beta-catenin is vital for the integrity of mouse embryonic stem cells.

β-Catenin mediated Wnt-signaling is assumed to play a major function in embryonic stem cells in maintaining their stem cell character and the exit from this unique trait. The complexity of β-catenin action and conflicting results on the role of β-catenin in maintaining the pluripotent state have mad...

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Bibliographic Details
Main Authors: Angelo Raggioli, Dirk Junghans, Stefan Rudloff, Rolf Kemler
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3897734?pdf=render