Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection

Uterus globulin associated protein 1 (UGRP1) binds podoplanin (PDPN) to promote a novel inflammation pathway during Streptococcus pneumoniae infection

Abstract Background Streptococcus pneumoniae is the major cause of life‐threatening infections. Toll‐like receptors (TLRs) and NOD‐like receptors (NLRs) could recognise S. pneumoniae and regulate the production of pro‐inflammatory cytokines. UGRP1, highly expressed in lung, is predominantly secreted...

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Bibliographic Details
Main Authors: Lei Han, Feifei Zhang, Yu Liu, Jie Yu, Qianyue Zhang, Xiaoping Ye, Huaidong Song, Cuixia Zheng, Bing Han
Format: Article
Language:English
Published: Wiley 2022-06-01
Series:Clinical and Translational Medicine
Subjects:
UGRP1
PDPN
macrophage
IL‐6
Online Access:https://doi.org/10.1002/ctm2.850

Internet

https://doi.org/10.1002/ctm2.850

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