A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection

A single mutation in the E2 glycoprotein of hepatitis C virus broadens the claudin specificity for its infection

Abstract Entry of the hepatitis C virus (HCV) into host cells is a multistep process mediated by several host factors, including a tight junction protein claudin-1 (CLDN1). We repeatedly passaged HCV-JFH1-tau, an HCV substrain with higher infectivity, on Huh7.5.1-8 cells. A multi-passaged HCV-JFH1-t...

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Bibliographic Details
Main Authors: Yoshitaka Shirasago, Hidesuke Fukazawa, Shotaro Nagase, Yoshimi Shimizu, Tomoharu Mizukami, Takaji Wakita, Tetsuro Suzuki, Hideki Tani, Masuo Kondoh, Takuya Kuroda, Satoshi Yasuda, Yoji Sato, Kentaro Hanada, Masayoshi Fukasawa
Format: Article
Language:English
Published: Nature Portfolio 2022-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-022-23824-3

Internet

https://doi.org/10.1038/s41598-022-23824-3

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