Preliminary evaluation of the antiglycoxidant activity of verapamil using various in vitro and in silico biochemical/biophysical methods

Preliminary evaluation of the antiglycoxidant activity of verapamil using various in vitro and in silico biochemical/biophysical methods

Introduction: Glycoxidative stress is essential for linking glucose disturbances and cardiovascular diseases. Unfortunately, contemporary antidiabetic drugs do not have an antiglycative effect but only lower blood glucose levels. Therefore, there is an intense search for substances that could inhibi...

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Main Authors: Miłosz Nesterowicz, Kamil Klaudiusz Lauko, Karolina Dańkowska, Daria Trocka, Małgorzata Żendzian-Piotrowska, Jerzy Robert Ładny, Anna Zalewska, Mateusz Maciejczyk
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-11-01
Series:Frontiers in Pharmacology
Subjects:
verapamil
diabetes mellitus
protein glycation
antiglycative activity
antioxidant activity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2023.1293295/full

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https://www.frontiersin.org/articles/10.3389/fphar.2023.1293295/full

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