Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury

Design, synthesis and anti-inflammatory activity study of lansiumamide analogues for treatment of acute lung injury

Acute lung injury (ALI) is an inflammation-mediated respiratory disease with a high mortality rate. Medications with anti-inflammatory small molecules have been demonstrated in phase I and II clinical trials to considerably reduce the ALI mortality. In this study, two series of lansiumamide analogue...

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Bibliographic Details
Main Authors: Liyan Song, Gang Li, Wen Guan, Zhijun Zeng, Yanghui Ou, Tongchao Zhao, Jiayu Li, Dengqin He, Xiangxiang Fang, Yali Zhang, Jia-qiang Wu, Rongbiao Tong, Hongliang Yao
Format: Article
Language:English
Published: Elsevier 2023-10-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Lansiumamide analogues
Anti-inflammatory
Nrf2/HO-1 pathway
Expectorant
ALI
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332223012106

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http://www.sciencedirect.com/science/article/pii/S0753332223012106

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