African swine fever virus ubiquitin-conjugating enzyme pI215L inhibits IFN-I signaling pathway through STAT2 degradation

African swine fever virus ubiquitin-conjugating enzyme pI215L inhibits IFN-I signaling pathway through STAT2 degradation

African swine fever virus (ASFV) is the causative agent of one of the most lethal diseases affecting domestic pig and wild boar, which is endangering the swine industry due to its rapid expansion. ASFV has developed different mechanisms to evade the host immune response, including inhibition of type...

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Bibliographic Details
Main Authors: Elena Riera, Raquel García-Belmonte, Ricardo Madrid, Daniel Pérez-Núñez, Yolanda Revilla
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-01-01
Series:Frontiers in Microbiology
Subjects:
ASFV
pI215L
ubiquitin-conjugating enzyme
IFN-I
STAT2
proteasomal degradation
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2022.1081035/full

Internet

https://www.frontiersin.org/articles/10.3389/fmicb.2022.1081035/full

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