Tafazzin modulates cellular phospholipid composition to regulate AML stemness

Tafazzin is a mitochondrial enzyme necessary for the remodeling of the phospholipid cardiolipin. Seneviratne and Xu et al. demonstrated that Tafazzin-mediated phospholipid production regulates stemness in Acute Myeloid Leukemia (AML). Tafazzin influenced intracellular levels of phospholipids to cont...

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Bibliographic Details
Main Authors: Ayesh K. Seneviratne, Mingjing Xu, Aaron D. Schimmer
Format: Article
Language:English
Published: Taylor & Francis Group 2019-09-01
Series:Molecular & Cellular Oncology
Subjects:
Online Access:http://dx.doi.org/10.1080/23723556.2019.1620051