Blocking interleukin-23 ameliorates neuromuscular and thymic defects in myasthenia gravis

Blocking interleukin-23 ameliorates neuromuscular and thymic defects in myasthenia gravis

Abstract Acetylcholine receptor (AChR) myasthenia gravis (MG) is a chronic autoimmune disease characterized by muscle weakness. The AChR+ autoantibodies are produced by B-cells located in thymic ectopic germinal centers (eGC). No therapeutic approach is curative. The inflammatory IL-23/Th17 pathway...

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Bibliographic Details
Main Authors: José A. Villegas, Jérôme Van Wassenhove, Judith Merrheim, Karen Matta, Samy Hamadache, Clémence Flaugère, Pauline Pothin, Frédérique Truffault, Sébastien Hascoët, Nicola Santelmo, Marco Alifano, Sonia Berrih-Aknin, Rozen le Panse, Nadine Dragin
Format: Article
Language:English
Published: BMC 2023-01-01
Series:Journal of Neuroinflammation
Subjects:
Autoimmunity
Inflammation
Neuromuscular junction
Germinal centers
Th17
Muscle regeneration
Online Access:https://doi.org/10.1186/s12974-023-02691-3

Internet

https://doi.org/10.1186/s12974-023-02691-3

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