Asiaticoside improves depressive-like behavior in mice with chronic unpredictable mild stress through modulation of the gut microbiota

BackgroundAsiaticoside, the main active ingredient of Centella asiatica, is a pentacyclic triterpenoid compound. Previous studies have suggested that asiaticoside possesses neuroprotective and anti-depressive properties, however, the mechanism of its anti-depressant action not fully understood. In r...

Full description

Bibliographic Details
Main Authors: Qingyi Ren, Chenxi He, Yuhong Sun, Xiaowei Gao, Yan Zhou, Tao Qin, Zhuo Zhang, Xiaodong Wang, Jun Wang, Siping Wei, Fang Wang
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-10-01
Series:Frontiers in Pharmacology
Subjects:
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2024.1461873/full