Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi

Rapamycin Improves the Response of Effector and Memory CD8+ T Cells Induced by Immunization With ASP2 of Trypanosoma cruzi

Deficiency in memory formation and increased immunosenescence are pivotal features of Trypanosoma cruzi infection proposed to play a role in parasite persistence and disease development. The vaccination protocol that consists in a prime with plasmid DNA followed by the boost with a deficient recombi...

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Bibliographic Details
Main Authors: Barbara Ferri Moraschi, Isaú Henrique Noronha, Camila Pontes Ferreira, Leonardo M. Cariste, Caroline B. Monteiro, Priscila Denapoli, Talita Vrechi, Gustavo J. S. Pereira, Ricardo T. Gazzinelli, Joseli Lannes-Vieira, Maurício M. Rodrigues, Karina R. Bortoluci, José Ronnie C. Vasconcelos
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Cellular and Infection Microbiology
Subjects:
rapamycin
mTOR
CD8+ T-cells
vaccine
Trypanosoma cruzi
effector CD8+ T cells
Online Access:https://www.frontiersin.org/articles/10.3389/fcimb.2021.676183/full

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https://www.frontiersin.org/articles/10.3389/fcimb.2021.676183/full

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