Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis

Self-propelled nanomotor reconstructs tumor microenvironment through synergistic hypoxia alleviation and glycolysis inhibition for promoted anti-metastasis

Solid tumors always exhibit local hypoxia, resulting in the high metastasis and inertness to chemotherapy. Reconstruction of hypoxic tumor microenvironment (TME) is considered a potential therapy compared to directly killing tumor cells. However, the insufficient oxygen delivery to deep tumor and th...

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Bibliographic Details
Main Authors: Wenqi Yu, Ruyi Lin, Xueqin He, Xiaotong Yang, Huilin Zhang, Chuan Hu, Rui Liu, Yuan Huang, Yi Qin, Huile Gao
Format: Article
Language:English
Published: Elsevier 2021-09-01
Series:Acta Pharmaceutica Sinica B
Subjects:
Nanomotor
Microenvironment modulation
Hypoxia
Aerobic glycolysis
Triple negative breast cancer
Anti-metastasis
Online Access:http://www.sciencedirect.com/science/article/pii/S2211383521001337

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http://www.sciencedirect.com/science/article/pii/S2211383521001337

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