Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes

Anti-TLR7 Antibody Protects Against Lupus Nephritis in NZBWF1 Mice by Targeting B Cells and Patrolling Monocytes

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by autoantibody production and multiple organ damage. Toll-like receptor 7 (TLR7), an innate immune RNA sensor expressed in monocytes/macrophages, dendritic cells (DCs), and B cells, promotes disease progression. However, litt...

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Bibliographic Details
Main Authors: Yusuke Murakami, Ryutaro Fukui, Reika Tanaka, Yuji Motoi, Atsuo Kanno, Ryota Sato, Kiyoshi Yamaguchi, Hirofumi Amano, Yoichi Furukawa, Hitoshi Suzuki, Yusuke Suzuki, Naoto Tamura, Naomi Yamashita, Kensuke Miyake
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Immunology
Subjects:
toll-like receptor
lupus nephritis
inhibitory monoclonal antibody
monocytes
autoantibody
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.777197/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.777197/full

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