Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-<i>b</i>]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase

Synthesis of a 3,7-Disubstituted Isothiazolo[4,3-<i>b</i>]pyridine as a Potential Inhibitor of Cyclin G-Associated Kinase

Disubstituted isothiazolo[4,3-<i>b</i>]pyridines are known inhibitors of cyclin G-associated kinase. Since 3-substituted-7-aryl-isothiazolo[4,3-<i>b</i>]pyridines remain elusive, a strategy was established to prepare this chemotype, starting from 2,4-dichloro-3-nitropyridine....

Full description

Bibliographic Details
Main Authors: Tom Grisez, Nitha Panikkassery Ravi, Mathy Froeyen, Dominique Schols, Luc Van Meervelt, Steven De Jonghe, Wim Dehaen
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:Molecules
Subjects:
GAK
isothiazolo[4,3-<i>b</i>]pyridine
kinase
inhibitor
Online Access:https://www.mdpi.com/1420-3049/29/5/954

Internet

https://www.mdpi.com/1420-3049/29/5/954

Similar Items