Continuous MYD88 Activation Is Associated With Expansion and Then Transformation of IgM Differentiating Plasma Cells

Continuous MYD88 Activation Is Associated With Expansion and Then Transformation of IgM Differentiating Plasma Cells

Activating mutations of MYD88 (MYD88L265P being the far most frequent) are found in most cases of Waldenström macroglobulinemia (WM) as well as in various aggressive B-cell lymphoma entities with features of plasma cell (PC) differentiation, such as activated B-cell type diffuse large B-cell lymphom...

Full description

Bibliographic Details
Main Authors: Catherine Ouk, Lilian Roland, Nathalie Gachard, Stéphanie Poulain, Christelle Oblet, David Rizzo, Alexis Saintamand, Quentin Lemasson, Claire Carrion, Morgane Thomas, Karl Balabanian, Marion Espéli, Marie Parrens, Isabelle Soubeyran, Mélanie Boulin, Nathalie Faumont, Jean Feuillard, Christelle Vincent-Fabert
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-05-01
Series:Frontiers in Immunology
Subjects:
MYD88 L265P mutation
lymphoplasmacytic lymphoma/Waldenstrom’s macroglobulinemia
IgM secretion
monoclonal Ig peak
B-cell lymphoma
plasma cell
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2021.641692/full

Internet

https://www.frontiersin.org/articles/10.3389/fimmu.2021.641692/full

Similar Items