Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions

Restricting tumor lactic acid metabolism using dichloroacetate improves T cell functions

Abstract Background Lactic acid produced by tumors has been shown to overcome immune surveillance, by suppressing the activation and function of T cells in the tumor microenvironment. The strategies employed to impair tumor cell glycolysis could improve immunosurveillance and tumor growth regulation...

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Bibliographic Details
Main Authors: Hosein Rostamian, Mohammad Khakpoor-Koosheh, Leila Jafarzadeh, Elham Masoumi, Keyvan Fallah-Mehrjardi, Mohammad Javad Tavassolifar, John M. Pawelek, Hamid Reza Mirzaei, Jamshid Hadjati
Format: Article
Language:English
Published: BMC 2022-01-01
Series:BMC Cancer
Subjects:
Metabolism
Lactic acid
Cancer
T cell
Dichloroacetate, Immunotherapy
Online Access:https://doi.org/10.1186/s12885-021-09151-2

Internet

https://doi.org/10.1186/s12885-021-09151-2

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