Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle

Optimization of Tilmicosin-Loaded Nanostructured Lipid Carriers Using Orthogonal Design for Overcoming Oral Administration Obstacle

Tilmicosin (TMS) is widely used to treat bacterial infections in veterinary medicine, but the clinical effect is limited by its poor solubility, bitterness, gastric instability, and intestinal efflux transport. Nanostructured lipid carriers (NLCs) are nowadays considered to be a promising vector of...

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Bibliographic Details
Main Authors: Jia Wen, Xiuge Gao, Qian Zhang, Benazir Sahito, Hongbin Si, Gonghe Li, Qi Ding, Wenda Wu, Eugenie Nepovimova, Shanxiang Jiang, Liping Wang, Kamil Kuca, Dawei Guo
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Pharmaceutics
Subjects:
tilmicosin
nanostructured lipid carriers
orthogonal design
intestinal absorption
MDCK-chAbcg2/Abcb1 cell monolayer
Online Access:https://www.mdpi.com/1999-4923/13/3/303

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https://www.mdpi.com/1999-4923/13/3/303

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