Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats

Bilobalide Exerts Anti-Inflammatory Effects on Chondrocytes Through the AMPK/SIRT1/mTOR Pathway to Attenuate ACLT-Induced Post-Traumatic Osteoarthritis in Rats

Although osteoarthritis (OA) significantly affects the quality of life of the elderly, there is still no effective treatment strategy. The standardized Ginkgo biloba L. extract preparation has been shown to have a wide range of therapeutic effects. Bilobalide, a unique ingredient of Ginkgo biloba, h...

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Bibliographic Details
Main Authors: Tianwen Ma, Liangyu Lv, Yue Yu, Lina Jia, Xiaopeng Song, XinYu Xu, Ting Li, Xuanbo Sheng, Haoran Wang, Jiantao Zhang, Li Gao
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-02-01
Series:Frontiers in Pharmacology
Subjects:
bilobalide
autophagy
AMPK/SIRT1/mTOR
inflammation
osteoarthritis
ACLT
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.783506/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.783506/full

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