BCR-ABL promotes PTEN downregulation in chronic myeloid leukemia.

BCR-ABL promotes PTEN downregulation in chronic myeloid leukemia.

Chronic myeloid leukemia (CML) is a myeloproliferative disorder characterized by the t(9;22) translocation coding for the chimeric protein p210 BCR-ABL. The tumor suppressor PTEN plays a critical role in the pathogenesis of CML chronic phase, through non genomic loss of function mechanisms, such as...

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Bibliographic Details
Main Authors: Cristina Panuzzo, Sabrina Crivellaro, Giovanna Carrà, Angelo Guerrasio, Giuseppe Saglio, Alessandro Morotti
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4208795?pdf=render

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http://europepmc.org/articles/PMC4208795?pdf=render

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