Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?

Genetic Biomarkers in Chronic Myeloid Leukemia: What Have We Learned So Far?

Chronic Myeloid Leukemia (CML) is a rare malignant proliferative disease of the hematopoietic system, whose molecular hallmark is the Philadelphia chromosome (Ph). The Ph chromosome originates an aberrant fusion gene with abnormal kinase activity, leading to the buildup of reactive oxygen species an...

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Bibliographic Details
Main Authors: Bilal Abdulmawjood, Beatriz Costa, Catarina Roma-Rodrigues, Pedro V. Baptista, Alexandra R. Fernandes
Format: Article
Language:English
Published: MDPI AG 2021-11-01
Series:International Journal of Molecular Sciences
Subjects:
chronic myeloid leukemia
Philadelphia chromosome
genetic biomarkers
miRNAs
genomic instability
Online Access:https://www.mdpi.com/1422-0067/22/22/12516

Internet

https://www.mdpi.com/1422-0067/22/22/12516

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