Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

Mechanical forces couple bone matrix mineralization with inhibition of angiogenesis to limit adolescent bone growth

The study shows that mechanical forces trigger secretion of the extracellular matrix protein dentin matrix protein 1 from osteoblasts. This transforms bone growth-promoting blood vessels into a quiescent subtype to limit bone growth at the end of adolescence.

Bibliographic Details
Main Authors: Maria Dzamukova, Tobias M. Brunner, Jadwiga Miotla-Zarebska, Frederik Heinrich, Laura Brylka, Mir-Farzin Mashreghi, Anjali Kusumbe, Ralf Kühn, Thorsten Schinke, Tonia L. Vincent, Max Löhning
Format: Article
Language:English
Published: Nature Portfolio 2022-06-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-30618-8

Internet

https://doi.org/10.1038/s41467-022-30618-8

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