The effect of sodium thiosulfate on immune cell metabolism during porcine hemorrhage and resuscitation

The effect of sodium thiosulfate on immune cell metabolism during porcine hemorrhage and resuscitation

IntroductionSodium thiosulfate (Na2S2O3), an H2S releasing agent, was shown to be organ-protective in experimental hemorrhage. Systemic inflammation activates immune cells, which in turn show cell type-specific metabolic plasticity with modifications of mitochondrial respiratory activity. Since H2S...

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Bibliographic Details
Main Authors: Eva-Maria Wolfschmitt, Melanie Hogg, Josef Albert Vogt, Fabian Zink, Ulrich Wachter, Felix Hezel, Xiaomin Zhang, Andrea Hoffmann, Michael Gröger, Clair Hartmann, Holger Gässler, Thomas Datzmann, Tamara Merz, Andreas Hellmann, Christine Kranz, Enrico Calzia, Peter Radermacher, David Alexander Christian Messerer
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-02-01
Series:Frontiers in Immunology
Subjects:
hemorrhagic shock
innate immunity
mitochondrial respiration
reactive oxygen species
immunometabolism
metabolic flux analysis
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125594/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125594/full

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