The effect of sodium thiosulfate on immune cell metabolism during porcine hemorrhage and resuscitation

The effect of sodium thiosulfate on immune cell metabolism during porcine hemorrhage and resuscitation

IntroductionSodium thiosulfate (Na2S2O3), an H2S releasing agent, was shown to be organ-protective in experimental hemorrhage. Systemic inflammation activates immune cells, which in turn show cell type-specific metabolic plasticity with modifications of mitochondrial respiratory activity. Since H2S...

Full description

Bibliographic Details
Main Authors:	Eva-Maria Wolfschmitt, Melanie Hogg, Josef Albert Vogt, Fabian Zink, Ulrich Wachter, Felix Hezel, Xiaomin Zhang, Andrea Hoffmann, Michael Gröger, Clair Hartmann, Holger Gässler, Thomas Datzmann, Tamara Merz, Andreas Hellmann, Christine Kranz, Enrico Calzia, Peter Radermacher, David Alexander Christian Messerer
Format:	Article
Language:	English
Published:	Frontiers Media S.A. 2023-02-01
Series:	Frontiers in Immunology
Subjects:	hemorrhagic shock innate immunity mitochondrial respiration reactive oxygen species immunometabolism metabolic flux analysis
Online Access:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1125594/full

Similar Items

The H2S Donor Sodium Thiosulfate (Na2S2O3) Does Not Improve Inflammation and Organ Damage After Hemorrhagic Shock in Cardiovascular Healthy Swine
by: David Alexander Christian Messerer, et al.
Published: (2022-06-01)

13C-Metabolic flux analysis detected a hyperoxemia-induced reduction of tricarboxylic acid cycle metabolism in granulocytes during two models of porcine acute subdural hematoma and hemorrhagic shock
by: Eva-Maria Wolfschmitt, et al.
Published: (2024-01-01)

The effect of targeted hyperoxemia in a randomized controlled trial employing a long-term resuscitated, model of combined acute subdural hematoma and hemorrhagic shock in swine with coronary artery disease: An exploratory, hypothesis-generating study
by: Thomas Datzmann, et al.
Published: (2022-08-01)

An exploratory study investigating the effect of targeted hyperoxemia in a randomized controlled trial in a long-term resuscitated model of combined acute subdural hematoma and hemorrhagic shock in cardiovascular healthy pigs
by: Thomas Datzmann, et al.
Published: (2023-04-01)

Target arterial PO2 according to the underlying pathology: a mini-review of the available data in mechanically ventilated patients
by: Julien Demiselle, et al.
Published: (2021-06-01)

H2S in acute lung injury: a therapeutic dead end(?)
by: Tamara Merz, et al.
Published: (2020-12-01)

H<sub>2</sub>S in Critical Illness—A New Horizon for Sodium Thiosulfate?
by: Tamara Merz, et al.
Published: (2022-04-01)

Bayesian <sup>13</sup>C-Metabolic Flux Analysis of Parallel Tracer Experiments in Granulocytes: A Directional Shift within the Non-Oxidative Pentose Phosphate Pathway Supports Phagocytosis
by: Melanie Hogg, et al.
Published: (2023-12-01)

Effects of Sodium Thiosulfate During Resuscitation From Trauma-and-Hemorrhage in Cystathionine-γ-Lyase Knockout Mice With Diabetes Type 1
by: Michael Gröger, et al.
Published: (2022-04-01)

Glucocorticoids coordinate macrophage metabolism through the regulation of the tricarboxylic acid cycle
by: Ulrich Stifel, et al.
Published: (2022-03-01)

Activation of Neutrophil Granulocytes by Platelet-Activating Factor Is Impaired During Experimental Sepsis
by: Stefan Hug, et al.
Published: (2021-03-01)

Basic Mechanisms of Immunometabolites in Shaping the Immune Response
by: Dylan Gerard Ryan, et al.
Published: (2023-11-01)

Ion and Water Transport in Neutrophil Granulocytes and Its Impairment during Sepsis
by: David Alexander Christian Messerer, et al.
Published: (2021-02-01)

Animal-Free Human Whole Blood Sepsis Model to Study Changes in Innate Immunity
by: David Alexander Christian Messerer, et al.
Published: (2020-10-01)

Block of Voltage-Gated Sodium Channels by Aripiprazole in a State-Dependent Manner
by: Karl Josef Föhr, et al.
Published: (2022-10-01)

Block of Voltage-Gated Sodium Channels by Atomoxetine in a State- and Use-dependent Manner
by: Karl Josef Föhr, et al.
Published: (2021-02-01)

Ex Vivo <sup>13</sup>C-Metabolic Flux Analysis of Porcine Circulating Immune Cells Reveals Cell Type-Specific Metabolic Patterns and Sex Differences in the Pentose Phosphate Pathway
by: Melanie Hogg, et al.
Published: (2024-01-01)

Relation of Plasma Catecholamine Concentrations and Myocardial Mitochondrial Respiratory Activity in Anesthetized and Mechanically Ventilated, Cardiovascular Healthy Swine
by: Nadja Abele, et al.
Published: (2023-12-01)

Impact of hyperglycemia on cystathionine-γ-lyase expression during resuscitated murine septic shock
by: Tamara Merz, et al.
Published: (2017-06-01)

Porcine blood cell and brain tissue energy metabolism: Effects of “early life stress”
by: Franziska Münz, et al.
Published: (2023-04-01)

Basal Cisternostomy for Severe TBI: Surgical Technique and Cadaveric Dissection
by: L. Giammattei, et al.
Published: (2022-05-01)

Block of Voltage-Gated Sodium Channels as a Potential Novel Anti-cancer Mechanism of TIC10
by: Eva Fuchs, et al.
Published: (2021-10-01)

Nitric Oxide Modulates Metabolic Processes in the Tumor Immune Microenvironment
by: Christopher L. McGinity, et al.
Published: (2021-06-01)

Immunometabolic reprogramming, another cancer hallmark
by: Vijay Kumar, et al.
Published: (2023-05-01)

The Challenges and Advantages of Distributed Fiber Optic Strain Monitoring in and on the Cementitious Matrix of Concrete Beams
by: Martin Weisbrich, et al.
Published: (2023-11-01)

Experimental Study on Concrete under Combined FRP–Steel Confinement
by: Stefan Kaeseberg, et al.
Published: (2020-10-01)

Survey of sequential convex programming and generalized Gauss-Newton methods*
by: Messerer Florian, et al.
Published: (2021-08-01)

Investigation of horizontal gene transfer of pathogenicity islands in Escherichia coli using next-generation sequencing.
by: Maxim Messerer, et al.
Published: (2017-01-01)

Fragmentation and bond strength of airborne diesel soot agglomerates
by: Messerer Armin, et al.
Published: (2008-06-01)

Relationship with the diaphragm to predict the surgical outcome in large and giant pituitary adenomas
by: Ethan Harel, et al.
Published: (2022-09-01)

Brain Histology and Immunohistochemistry After Resuscitation From Hemorrhagic Shock in Swine With Pre-Existing Atherosclerosis and Sodium Thiosulfate (Na2S2O3) Treatment
by: Nicole Denoix, et al.
Published: (2022-06-01)

How many metabolic challenges for immune cells in health and disease?
by: Christian eFrezza, et al.
Published: (2015-06-01)

Multimodal analysis of granulocytes, monocytes, and platelets in patients with cystic fibrosis before and after Elexacaftor–Tezacaftor–Ivacaftor treatment
by: Hanna Schmidt, et al.
Published: (2023-06-01)

Indoximod: An Immunometabolic Adjuvant That Empowers T Cell Activity in Cancer
by: Eric Fox, et al.
Published: (2018-09-01)

Musculoskeletal Progenitor/Stromal Cell-Derived Mitochondria Modulate Cell Differentiation and Therapeutical Function
by: Christian Jorgensen, et al.
Published: (2021-03-01)

Electrophile Modulation of Inflammation: A Two-Hit Approach
by: James O’Brien, et al.
Published: (2020-11-01)

The Role of Metabolic Enzymes in the Regulation of Inflammation
by: Wesley H. Godfrey, et al.
Published: (2020-10-01)

Low circulatory levels of total cholesterol, HDL-C and LDL-C are associated with death of patients with sepsis and critical illness: systematic review, meta-analysis, and perspective of observational studiesResearch in context
by: Rory Taylor, et al.
Published: (2024-02-01)

Editorial: Targeting Indoleamine 2,3-dioxygenases and Tryptophan Dioxygenase for Cancer Immunotherapy
by: Lieve Brochez, et al.
Published: (2021-12-01)

An Exploratory Study Using Next-Generation Sequencing to Identify Prothrombotic Variants in Patients with Cerebral Vein Thrombosis
by: Robert Anton Kramer, et al.
Published: (2023-04-01)