Endoplasmic reticulum stress as a novel target to inhibit transdifferentiation of human retinal pigment epithelial cells

Background: The epithelial to mesenchymal transition (EMT) of retinal pigment epithelial (RPE) cells is a critical event in the pathogenesis of proliferative vitreoretinopathy and neovascular age-related macular degeneration, which are the leading causes of severe vision loss. Endoplasmic reticulum...

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Bibliographic Details
Main Authors: Sha Ouyang, Dan Ji, Shikun He, Xiaobo Xia
Format: Article
Language:English
Published: IMR Press 2022-01-01
Series:Frontiers in Bioscience-Landmark
Subjects:
Online Access:https://www.imrpress.com/journal/FBL/27/2/10.31083/j.fbl2702038