The benefit of co-targeting PARP-1 and c-Met on the efficacy of radiotherapy in wild type BRAF melanoma

The benefit of co-targeting PARP-1 and c-Met on the efficacy of radiotherapy in wild type BRAF melanoma

Melanoma is known to be a radioresistant cancer. Melanoma radioresistance can be due to several factors such as pigmentation, antioxidant defenses and high Deoxyribonucleic acid (DNA) repair efficacy. However, irradiation induces intracellular translocation of RTKs, including cMet, which regulates r...

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Bibliographic Details
Main Authors: Malak Sabbah, Ahmad Najem, Christophe Vanderkerkhove, Fabien Kert, Younes Jourani, Fabrice Journe, Ahmad Awada, Dirk Van Gestel, Ghanem E. Ghanem, Mohammad Krayem
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-05-01
Series:Frontiers in Medicine
Subjects:
melanoma
radiotherapy
WTBRAF
RTK inhibition
PARP inhibition
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2023.1149918/full

Internet

https://www.frontiersin.org/articles/10.3389/fmed.2023.1149918/full

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