Real-life effects of dupilumab in patients with severe type 2 asthma, according to atopic trait and presence of chronic rhinosinusitis with nasal polyps

Real-life effects of dupilumab in patients with severe type 2 asthma, according to atopic trait and presence of chronic rhinosinusitis with nasal polyps

BackgroundThe efficacy of dupilumab as biological treatment of severe asthma and chronic rhinosinusitis with nasal polyps (CRSwNP) depends on its ability to inhibit the pathophysiologic mechanisms involved in type 2 inflammation.ObjectiveTo assess in a large sample of subjects with severe asthma, th...

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Main Authors: Corrado Pelaia, Alida Benfante, Maria Teresa Busceti, Maria Filomena Caiaffa, Raffaele Campisi, Giovanna Elisiana Carpagnano, Nunzio Crimi, Maria D’Amato, Maria Pia Foschino Barbaro, Angelantonio Maglio, Elena Minenna, Santi Nolasco, Giuseppe Paglino, Francesco Papia, Girolamo Pelaia, Andrea Portacci, Luisa Ricciardi, Nicola Scichilone, Giulia Scioscia, Massimo Triggiani, Giuseppe Valenti, Alessandro Vatrella, Claudia Crimi
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-03-01
Series:Frontiers in Immunology
Subjects:
severe asthma
nasal polyps
interleukin 4
interleukin 13
dupilumab
clinical remission
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121237/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1121237/full

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