Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex

Association of neurogranin gene expression with Alzheimer's disease pathology in the perirhinal cortex

Abstract Introduction Synaptic damage is a key pathology of Alzheimer's disease (AD). The mechanism underlying synaptic vulnerability in AD remains elusive. Methods Using a large‐scale transcriptomic dataset, we analyzed the neurogranin‐centered integrative gene network and assessed the correla...

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Bibliographic Details
Main Authors: Xiaoyan Sun, Qian Wang, Kaj Blennow, Henrik Zetterberg, Micheline McCarthy, David A. Loewenstein, Regina Vontell, Zhenyu Yue, Bin Zhang
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Alzheimer’s & Dementia: Translational Research & Clinical Interventions
Subjects:
Alzheimer's disease
amyloid
integrative gene network
neurogranin
perirhinal cortex
synapse
Online Access:https://doi.org/10.1002/trc2.12162

Internet

https://doi.org/10.1002/trc2.12162

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