Interferon Gamma Enhances Cytoprotective Pathways via Nrf2 and MnSOD Induction in Friedreich’s Ataxia Cells

Interferon Gamma Enhances Cytoprotective Pathways via Nrf2 and MnSOD Induction in Friedreich’s Ataxia Cells

Friedreich’s ataxia (FRDA) is a rare monogenic disease characterized by multisystem, slowly progressive degeneration. Because of the genetic defect in a non-coding region of <i>FXN</i> gene, FRDA cells exhibit severe deficit of frataxin protein levels. Hence, FRDA pathophysiology is char...

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Bibliographic Details
Main Authors: Riccardo Luffarelli, Luca Panarello, Andrea Quatrana, Francesca Tiano, Silvia Fortuni, Alessandra Rufini, Florence Malisan, Roberto Testi, Ivano Condò
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:International Journal of Molecular Sciences
Subjects:
Friedreich’s ataxia
interferon gamma
cytoprotection
Nrf2
MnSOD
Online Access:https://www.mdpi.com/1422-0067/24/16/12687

Internet

https://www.mdpi.com/1422-0067/24/16/12687

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