Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1

Over-expressed microRNA-181a reduces glomerular sclerosis and renal tubular epithelial injury in rats with chronic kidney disease via down-regulation of the TLR/NF-κB pathway by binding to CRY1

Abstract Background MicroRNAs (miRNAs) contribute to the progression of chronic kidney disease (CKD) by regulating renal homeostasis. This study explored the effects of miR-181a on CKD through the Toll-like receptor (TLR)/nuclear factor-kappa B (NF-κB) pathway by binding to CRY1. Methods Seventy mal...

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Bibliographic Details
Main Authors: Lei Liu, Xin-Lu Pang, Wen-Jun Shang, Hong-Chang Xie, Jun-Xiang Wang, Gui-Wen Feng
Format: Article
Language:English
Published: BMC 2018-09-01
Series:Molecular Medicine
Subjects:
MicroRNA-181a
CRY1 gene
The TLR/NF-κB pathway
Chronic kidney disease
Glomerular sclerosis
Renal tubular epithelial injury
Online Access:http://link.springer.com/article/10.1186/s10020-018-0045-2

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http://link.springer.com/article/10.1186/s10020-018-0045-2

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