Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody

Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody

Auxiliary subunit molecular diversity is an unexploited target for developing ion channel inhibitors. Here, the authors develop a general approach to inhibit ion channels based on the resident auxiliary subunit isoform to elucidate unique functions of distinct ion channel macromolecular complexes.

Bibliographic Details
Main Authors: Travis J. Morgenstern, Neha Nirwan, Erick O. Hernández-Ochoa, Hugo Bibollet, Papiya Choudhury, Yianni D. Laloudakis, Manu Ben Johny, Roger A. Bannister, Martin F. Schneider, Daniel L. Minor, Henry M. Colecraft
Format: Article
Language:English
Published: Nature Portfolio 2022-12-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-35025-7

Internet

https://doi.org/10.1038/s41467-022-35025-7

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