Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody
Auxiliary subunit molecular diversity is an unexploited target for developing ion channel inhibitors. Here, the authors develop a general approach to inhibit ion channels based on the resident auxiliary subunit isoform to elucidate unique functions of distinct ion channel macromolecular complexes.
Bibliographic Details
| Main Authors: |
Travis J. Morgenstern,
Neha Nirwan,
Erick O. Hernández-Ochoa,
Hugo Bibollet,
Papiya Choudhury,
Yianni D. Laloudakis,
Manu Ben Johny,
Roger A. Bannister,
Martin F. Schneider,
Daniel L. Minor,
Henry M. Colecraft |
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| Format: | Article
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| Language: | English |
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| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications
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| Online Access: | https://doi.org/10.1038/s41467-022-35025-7
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