Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody
Auxiliary subunit molecular diversity is an unexploited target for developing ion channel inhibitors. Here, the authors develop a general approach to inhibit ion channels based on the resident auxiliary subunit isoform to elucidate unique functions of distinct ion channel macromolecular complexes.
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-12-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-35025-7 |
| _version_ | 1828277803670306816 |
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| author | Travis J. Morgenstern Neha Nirwan Erick O. Hernández-Ochoa Hugo Bibollet Papiya Choudhury Yianni D. Laloudakis Manu Ben Johny Roger A. Bannister Martin F. Schneider Daniel L. Minor Henry M. Colecraft |
| author_facet | Travis J. Morgenstern Neha Nirwan Erick O. Hernández-Ochoa Hugo Bibollet Papiya Choudhury Yianni D. Laloudakis Manu Ben Johny Roger A. Bannister Martin F. Schneider Daniel L. Minor Henry M. Colecraft |
| author_sort | Travis J. Morgenstern |
| collection | DOAJ |
| description | Auxiliary subunit molecular diversity is an unexploited target for developing ion channel inhibitors. Here, the authors develop a general approach to inhibit ion channels based on the resident auxiliary subunit isoform to elucidate unique functions of distinct ion channel macromolecular complexes. |
| first_indexed | 2024-04-13T07:20:20Z |
| format | Article |
| id | doaj.art-6afcd6383eb345e8b49429eb383e8ae1 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T07:20:20Z |
| publishDate | 2022-12-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-6afcd6383eb345e8b49429eb383e8ae12022-12-22T02:56:38ZengNature PortfolioNature Communications2041-17232022-12-0113111910.1038/s41467-022-35025-7Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobodyTravis J. Morgenstern0Neha Nirwan1Erick O. Hernández-Ochoa2Hugo Bibollet3Papiya Choudhury4Yianni D. Laloudakis5Manu Ben Johny6Roger A. Bannister7Martin F. Schneider8Daniel L. Minor9Henry M. Colecraft10Department of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical CenterCardiovascular Research Institute, University of CaliforniaDepartment of Biochemistry and Biology, University of Maryland School of MedicineDepartment of Biochemistry and Biology, University of Maryland School of MedicineDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical CenterVagelos College of Physicians and Surgeons, Columbia University Irving Medical CenterDepartment of Physiology and Cellular Biophysics, Columbia University Irving Medical CenterDepartment of Biochemistry and Biology, University of Maryland School of MedicineDepartment of Biochemistry and Biology, University of Maryland School of MedicineCardiovascular Research Institute, University of CaliforniaDepartment of Molecular Pharmacology and Therapeutics, Columbia University Irving Medical CenterAuxiliary subunit molecular diversity is an unexploited target for developing ion channel inhibitors. Here, the authors develop a general approach to inhibit ion channels based on the resident auxiliary subunit isoform to elucidate unique functions of distinct ion channel macromolecular complexes.https://doi.org/10.1038/s41467-022-35025-7 |
| spellingShingle | Travis J. Morgenstern Neha Nirwan Erick O. Hernández-Ochoa Hugo Bibollet Papiya Choudhury Yianni D. Laloudakis Manu Ben Johny Roger A. Bannister Martin F. Schneider Daniel L. Minor Henry M. Colecraft Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody Nature Communications |
| title | Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody |
| title_full | Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody |
| title_fullStr | Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody |
| title_full_unstemmed | Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody |
| title_short | Selective posttranslational inhibition of CaVβ1-associated voltage-dependent calcium channels with a functionalized nanobody |
| title_sort | selective posttranslational inhibition of cavβ1 associated voltage dependent calcium channels with a functionalized nanobody |
| url | https://doi.org/10.1038/s41467-022-35025-7 |
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