Downregulation of LKB1/AMPK Signaling in Blood Mononuclear Cells Is Associated with the Severity of Guillain–Barre Syndrome

Downregulation of LKB1/AMPK Signaling in Blood Mononuclear Cells Is Associated with the Severity of Guillain–Barre Syndrome

AMP-activated protein kinase (AMPK) is an intracellular energy sensor that regulates metabolic and immune functions mainly through the inhibition of the mechanistic target of rapamycin (mTOR)-dependent anabolic pathways and the activation of catabolic processes such as autophagy. The AMPK/mTOR signa...

Full description

Bibliographic Details
Main Authors: Verica Paunovic, Stojan Peric, Irena Vukovic, Marina Stamenkovic, Emina Milosevic, Danijela Stevanovic, Milos Mandic, Ivana Basta, Ivana Berisavac, Mirjana Arsenijevic, Ivo Bozovic, Marko Nikolic, Zorica Stevic, Vladimir Trajkovic
Format: Article
Language:English
Published: MDPI AG 2022-09-01
Series:Cells
Subjects:
Guillain–Barré syndrome
peripheral blood mononuclear cells
AMP-activated protein kinase
autophagy
mTOR
metformin
Online Access:https://www.mdpi.com/2073-4409/11/18/2897

Internet

https://www.mdpi.com/2073-4409/11/18/2897

Similar Items