Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles

Selection of Cryoprotectant in Lyophilization of Progesterone-Loaded Stearic Acid Solid Lipid Nanoparticles

Cryoprotectants are often required in lyophilization to reduce or eliminate agglomeration of solute or suspended materials. The aim of this study was to select a cryoprotecting agent and optimize its concentration in a solid lipid nanoparticle formulation. Progesterone-loaded stearic acid solid lipi...

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Bibliographic Details
Main Authors: Timothy M. Amis, Jwala Renukuntla, Pradeep Kumar Bolla, Bradley A. Clark
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:Pharmaceutics
Subjects:
solid lipid nanoparticles
cryoprotectant
lyophilization
trehalose
surfactants
freezing rate
Online Access:https://www.mdpi.com/1999-4923/12/9/892

Internet

https://www.mdpi.com/1999-4923/12/9/892

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