Integrated transcriptomics uncovers an enhanced association between the prion protein gene expression and vesicle dynamics signatures in glioblastomas

Integrated transcriptomics uncovers an enhanced association between the prion protein gene expression and vesicle dynamics signatures in glioblastomas

Abstract Background Glioblastoma (GBM) is an aggressive brain tumor that exhibits resistance to current treatment, making the identification of novel therapeutic targets essential. In this context, cellular prion protein (PrPC) stands out as a potential candidate for new therapies. Encoded by the PR...

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Bibliographic Details
Main Authors: Jacqueline Marcia Boccacino, Rafael dos Santos Peixoto, Camila Felix de Lima Fernandes, Giovanni Cangiano, Paula Rodrigues Sola, Bárbara Paranhos Coelho, Mariana Brandão Prado, Maria Isabel Melo-Escobar, Breno Pereira de Sousa, Shamini Ayyadhury, Gary D. Bader, Sueli Mieko Oba Shinjo, Suely Kazue Nagahashi Marie, Edroaldo Lummertz da Rocha, Marilene Hohmuth Lopes
Format: Article
Language:English
Published: BMC 2024-02-01
Series:BMC Cancer
Subjects:
Glioblastoma
Transcriptomics
Prion protein
Intracellular trafficking
Vesicle dynamics
Online Access:https://doi.org/10.1186/s12885-024-11914-6

Internet

https://doi.org/10.1186/s12885-024-11914-6

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