Changes in Ionic Conductance Signature of Nociceptive Neurons Underlying Fabry Disease Phenotype

Changes in Ionic Conductance Signature of Nociceptive Neurons Underlying Fabry Disease Phenotype

The first symptom arising in many Fabry patients is neuropathic pain due to changes in small myelinated and unmyelinated fibers in the periphery, which is subsequently followed by a loss of sensory perception. Here we studied changes in the peripheral nervous system of Fabry patients and a Fabry mou...

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Bibliographic Details
Main Authors: Barbara Namer, Kirstin Ørstavik, Roland Schmidt, Norbert Mair, Inge Petter Kleggetveit, Maximillian Zeidler, Theresa Martha, Ellen Jorum, Martin Schmelz, Theodora Kalpachidou, Michaela Kress, Michiel Langeslag
Format: Article
Language:English
Published: Frontiers Media S.A. 2017-07-01
Series:Frontiers in Neurology
Subjects:
Fabry disease
lysosomal storage disorder
single fiber recordings
neuronal excitability
electrophysiology
nociception
Online Access:http://journal.frontiersin.org/article/10.3389/fneur.2017.00335/full

Internet

http://journal.frontiersin.org/article/10.3389/fneur.2017.00335/full

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