Inhibition of Abl Kinase by Imatinib Can Rescue the Compromised Barrier Function of 22q11.2DS Patient-iPSC-Derived Blood–Brain Barriers

Inhibition of Abl Kinase by Imatinib Can Rescue the Compromised Barrier Function of 22q11.2DS Patient-iPSC-Derived Blood–Brain Barriers

We have previously established that the integrity of the induced blood–brain barrier (iBBB) formed by brain microvascular endothelial cells derived from the iPSC of 22q11.2 DS (22q11.2 Deletion Syndrome, also called DiGeorge Syndrome) patients is compromised. We tested the possibility that the haplo...

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Bibliographic Details
Main Authors: Yunfei Li, Zhixiong Sun, Huixiang Zhu, Yan Sun, David B. Shteyman, Sander Markx, Kam W. Leong, Bin Xu, Bingmei M. Fu
Format: Article
Language:English
Published: MDPI AG 2023-01-01
Series:Cells
Subjects:
blood–brain barrier
imatinib
DiGeorge Syndrome
endothelial glycocalyx
tight junction
permeability
Online Access:https://www.mdpi.com/2073-4409/12/3/422

Internet

https://www.mdpi.com/2073-4409/12/3/422

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