PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells

PAI-1 Regulation of p53 Expression and Senescence in Type II Alveolar Epithelial Cells

Cellular senescence contributes importantly to aging and aging-related diseases, including idiopathic pulmonary fibrosis (IPF). Alveolar epithelial type II (ATII) cells are progenitors of alveolar epithelium, and ATII cell senescence is evident in IPF. Previous studies from this lab have shown that...

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Bibliographic Details
Main Authors: Tapasi Rana, Chunsun Jiang, Sami Banerjee, Nengjun Yi, Jaroslaw W. Zmijewski, Gang Liu, Rui-Ming Liu
Format: Article
Language:English
Published: MDPI AG 2023-08-01
Series:Cells
Subjects:
PAI-1
proteasome activity
p53 degradation
ATII cell senescence
Online Access:https://www.mdpi.com/2073-4409/12/15/2008

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https://www.mdpi.com/2073-4409/12/15/2008

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