A unified approach for quantifying and interpreting DNA shape readout by transcription factors

A unified approach for quantifying and interpreting DNA shape readout by transcription factors

Abstract Transcription factors (TFs) interpret DNA sequence by probing the chemical and structural properties of the nucleotide polymer. DNA shape is thought to enable a parsimonious representation of dependencies between nucleotide positions. Here, we propose a unified mathematical representation o...

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Bibliographic Details
Main Authors: H Tomas Rube, Chaitanya Rastogi, Judith F Kribelbauer, Harmen J Bussemaker
Format: Article
Language:English
Published: Springer Nature 2018-02-01
Series:Molecular Systems Biology
Subjects:
DNA binding specificity
DNA shape
sequence‐readout mechanisms
statistical analysis
transcription factors
Online Access:https://doi.org/10.15252/msb.20177902

Internet

https://doi.org/10.15252/msb.20177902

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