Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus

Urine ALCAM, PF4 and VCAM-1 Surpass Conventional Metrics in Identifying Nephritis Disease Activity in Childhood-Onset Systemic Lupus Erythematosus

ObjectivesSerial kidney biopsy for repeat evaluation and monitoring of lupus nephritis (LN) in childhood-onset Systemic Lupus Erythematosus (cSLE) remains challenging, thus non-invasive biomarkers are needed. Here, we evaluate the performance of ten urine protein markers of diverse nature including...

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Bibliographic Details
Main Authors: Samar A. Soliman, Anam Haque, Kamala Vanarsa, Ting Zhang, Faten Ismail, Kyung Hyun Lee, Claudia Pedroza, Larry A. Greenbaum, Sherene Mason, M. John Hicks, Scott E. Wenderfer, Chandra Mohan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Immunology
Subjects:
ALCAM
VCAM 1
PF4
urine
biomarker
childhood-onset lupus
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2022.885307/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2022.885307/full

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