HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

HIF-1 inactivation empowers HIF-2 to drive hypoxia adaptation in aggressive forms of medulloblastoma

Abstract Medulloblastoma (MB) is the most prevalent brain cancer in children. Four subgroups of MB have been identified; of these, Group 3 is the most metastatic. Its genetics and biology remain less clear than the other groups, and it has a poor prognosis and few effective treatments available. Tum...

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Bibliographic Details
Main Authors: J. Contenti, Y. Guo, M. Larcher, L. Mirabal-Ortega, M. Rouleau, M. Irondelle, V. Tiroille, A. Mazzu, V. Duranton-Tanneur, F. Pedeutour, I. Ben-Sahra, C. Lago, G. Leva, L. Tiberi, G. Robert, C. Pouponnot, F. Bost, N. M. Mazure
Format: Article
Language:English
Published: Nature Publishing Group 2024-07-01
Series:Cell Death Discovery
Online Access:https://doi.org/10.1038/s41420-024-02100-5

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https://doi.org/10.1038/s41420-024-02100-5

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